We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5′-[beta gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.
Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase
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L M Blayney, P W Gapper, A C Newby; Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase. Biochem J 1 February 1991; 273 (3): 803–806. doi: https://doi.org/10.1042/bj2730803
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