The concentration-dependent effects of a series of lipoxygenase inhibitors and antioxidants on the macrophage-mediated oxidative modification of low-density lipoprotein (LDL) were measured. Their influence on macrophage 5-lipoxygenase pathway activity was also studied over the same concentration range. No correlation between inhibition of 5-lipoxygenase and of macrophage-mediated oxidation of LDL was observed. The capacity of the compounds to prevent cell-mediated modification of LDL could be explained in terms of their activity as either aqueous- or lipid-peroxyl radical scavengers. Two potent 5-lipoxygenase inhibitors (MK 886 and Revlon 5901), which had no radical-scavenging properties, were unable to block LDL modification. It is concluded that 5-lipoxygenase is not essential for LDL oxidation by macrophages.
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Research Article| August 15 1991
5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein
Biochem J (1991) 278 (1): 163–169.
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W Jessup, V Darley-Usmar, V O'Leary, S Bedwell; 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochem J 15 August 1991; 278 (1): 163–169. doi: https://doi.org/10.1042/bj2780163
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