The inhibition of fluoride of sulphatase A from ox liver and of the sulphatases of Helix pomatia and Aspergillus oryzae is decreased by EDTA and increased by Al3+ or Be2+, implicating aluminofluorides and beryllofluorides in the reaction. The inhibition, which is reversible, takes several minutes to develop fully and, at least for the sulphatase of H. pomatia, is of a non-linear mixed competitive-non-competitive type. It is suggested that the aluminofluorides and beryllofluorides are acting as analogues of HSO4-. If so, then this behaviour must be considered, as well as their role as analogues of phosphate, in interpreting the effects of these compounds in intact cells.
Research Article| October 15 1991
Aluminofluorides and beryllofluorides as inhibitors of sulphatases. Analogues of hydrogen sulphate?
Biochem J (1991) 279 (2): 361–365.
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A B Roy; Aluminofluorides and beryllofluorides as inhibitors of sulphatases. Analogues of hydrogen sulphate?. Biochem J 15 October 1991; 279 (2): 361–365. doi: https://doi.org/10.1042/bj2790361
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