Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5′-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.
Research Article| January 01 1992
Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes
Biochem J (1992) 281 (1): 41-43.
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R Hertz, J Bar-Tana; Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes. Biochem J 1 January 1992; 281 (1): 41–43. doi: https://doi.org/10.1042/bj2810041
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