Mutations in the age-1 gene double both the mean and maximum life span of Caenorhabditis elegans. They also result in an age-specific increase of catalase and Cu/Zn superoxide dismutase activity levels. The higher superoxide dismutase activity levels in age-1 mutants confer hyperresistance to the superoxide-anion-generating drug paraquat. The rate of superoxide anion production by microsome fractions declines linearly with age in age-1(+) worms, but, after an initial decline, is stabilized at a higher level in senescent age-1 mutant nematodes. These results clearly show that oxidative stress resistance and potential life span are correlated in this organism, and they suggest that the natural product of age-1 either directly or indirectly downregulates the activities of several other genes as a function of age.
Research Article| June 01 1993
Oxidative stress and ageing in Caenorhabditis elegans
Biochem J (1993) 292 (2): 605-608.
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J R Vanfleteren; Oxidative stress and ageing in Caenorhabditis elegans. Biochem J 1 June 1993; 292 (2): 605–608. doi: https://doi.org/10.1042/bj2920605
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