Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.
Research Article| February 01 1994
Some taste substances are direct activators of G-proteins
*Institut für Pharmakologie, Freie Universität Berlin, D-14195 Berlin, Federal Republic of Germany
†Department of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76-100, Israel
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Biochem J (1994) 297 (3): 451–454.
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M Naim, R Seifert, B Nürnberg, L Grünbaum, G Schultz; Some taste substances are direct activators of G-proteins. Biochem J 1 February 1994; 297 (3): 451–454. doi: https://doi.org/10.1042/bj2970451
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