In the vertebrate photoreceptor cell, rod outer segment (ROS) is the site of visual signal-transduction process, and a pivotal molecule that regulates this process is cyclic GMP. Cyclic GMP controls the cationic conductance into the ROS, and light causes a decrease in the conductance by activating hydrolysis of the cyclic nucleotide. The identity of the granylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC.
Structural and functional characterization of the rod outer segment membrane guanylate cyclase
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R M Goraczniak, T Duda, A Sitaramayya, R K Sharma; Structural and functional characterization of the rod outer segment membrane guanylate cyclase. Biochem J 1 September 1994; 302 (2): 455–461. doi: https://doi.org/10.1042/bj3020455
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