The complete sequence of human gamma s-crystallin has been determined and confirmed using a combination of MS methods, peptide sequencing and cDNA sequencing. Regions 21-35 and 102-107, which were previously assumed to be the same as the bovine sequence, differ from the bovine sequence at residues 22, 28, 31 and 104. An additional six residues were also found to be different from the original sequence determined for Pakastani lenses. Whether these differences represent errors in the original sequence or two different sequences among human lens crystallins is not yet known.
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Research Article| April 15 1995
The complete sequence of human lens γs-crystallin
J B Smith;
Biochem J (1995) 307 (2): 407–410.
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J B Smith, Z Yang, P Lin, Z Zaidi, A Abbasi, P Russell; The complete sequence of human lens γs-crystallin. Biochem J 15 April 1995; 307 (2): 407–410. doi: https://doi.org/10.1042/bj3070407
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