Herpes simplex virus immediate-early (IE) promoters contain the TAATGARAT motif which acts as a target site for the cellular POU family transcription factors Oct-1 and Oct-2. Here we show that other members of the POU family that are expressed in sensory neurons can also affect IE promoter activity. In particular, two members of the Brn-3 family of POU proteins Brn-3a and Brn-3c can activate the IE-1 and IE-3 promoters when co-transfected into fibroblasts and neuronal cells whereas a third member Brn-3b represses IE promoter activity. In contrast, Brn-3 proteins cannot overcome the inhibitory effect of neuronal Oct-2 on IE promoter activity in co-transfections nor do they prevent transactivation of the IE promoters by the Oct-1-Vmw65 complex. The potential regulation of the IE promoters by several different neuronally expressed POU proteins during the initiation, maintenance and re-activation of latent infection in sensory neurons is discussed.
Skip Nav Destination
Article navigation
April 1995
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Research Article|
April 15 1995
Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors
K A Lillycrop;
K A Lillycrop
*Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, The Windeyer Building, Cleveland Street, London WlP 6DB, U.K.
Search for other works by this author on:
Y Z Liu;
Y Z Liu
*Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, The Windeyer Building, Cleveland Street, London WlP 6DB, U.K.
Search for other works by this author on:
T Theil;
T Theil
†Institut Für Molekularbiologie und Tumourforschung, Philipps Universität Marburg, Emil Mannkopff-Strasse 2, D-35037, Marburg, Germany
Search for other works by this author on:
T Möröy;
T Möröy
†Institut Für Molekularbiologie und Tumourforschung, Philipps Universität Marburg, Emil Mannkopff-Strasse 2, D-35037, Marburg, Germany
Search for other works by this author on:
D S Latchman
D S Latchman
*Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, The Windeyer Building, Cleveland Street, London WlP 6DB, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 1995 The Biochemical Society, London
1995
Biochem J (1995) 307 (2): 581–584.
Citation
K A Lillycrop, Y Z Liu, T Theil, T Möröy, D S Latchman; Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. Biochem J 15 April 1995; 307 (2): 581–584. doi: https://doi.org/10.1042/bj3070581
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.