We examined the expression of lipoprotein lipase (LPL) gene and LPL activity following a two-thirds hepatectomy and during liver regeneration. In most of the tissues studied, LPL activity increased a few hours after partial hepatectomy, but soon returned to normal levels. The greatest increase was found in the adrenal glands, plasma and liver. This increase in LPL activity in the liver could be partially due to an increase in the influx of the enzyme from extrahepatic tissues. There is, however, also a re-expression of LPL mRNA in the liver after partial hepatectomy (during the first hours). It is well known that LPL is expressed in the liver of neonatal animals, but progressively decreases during post-natal development, to reach adult levels around the time of weaning. Our results show by the first time that the remaining liver re-expresses LPL gene during the regeneration process and that the hepatocytes de-differentiate and acquire some of the neonatal characteristics. The increase in LPL mRNA will contribute to the rise in LPL activity after hepatectomy. This presence of LPL could enable the liver to take up fatty acids from the circulating triacylglycerols, which are needed as energetic and plastic substrates during the process of hepatic regeneration.
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September 1996
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Research Article|
September 01 1996
Hepatic regeneration induces changes in lipoprotein lipase activity in several tissues and its re-expression in the liver
Rosa SABUGAL;
Rosa SABUGAL
*Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08071 Barcelona, Spain
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Monique Q ROBERT;
Monique Q ROBERT
*Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08071 Barcelona, Spain
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Josep JULVE;
Josep JULVE
*Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08071 Barcelona, Spain
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Johan AUWERX;
Johan AUWERX
†Laboratoire de Biologie des régulations chez les Eucaryotes, 4325 INSERM, Département d'Athérosclerose, Institute Pasteur, Lille, France
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Miquel LLOBERA;
Miquel LLOBERA
*Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08071 Barcelona, Spain
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Julia PEINADO-ONSURBE
Julia PEINADO-ONSURBE
‡
*Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08071 Barcelona, Spain
‡To whom correspondence should be addressed.
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Publisher: Portland Press Ltd
Received:
January 03 1996
Revision Received:
April 22 1996
Accepted:
May 08 1996
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London © 1996
1996
Biochem J (1996) 318 (2): 597–602.
Article history
Received:
January 03 1996
Revision Received:
April 22 1996
Accepted:
May 08 1996
Citation
Rosa SABUGAL, Monique Q ROBERT, Josep JULVE, Johan AUWERX, Miquel LLOBERA, Julia PEINADO-ONSURBE; Hepatic regeneration induces changes in lipoprotein lipase activity in several tissues and its re-expression in the liver. Biochem J 1 September 1996; 318 (2): 597–602. doi: https://doi.org/10.1042/bj3180597
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