Galactosamine was found consistently as a minor component of the envelope of five species of slow-growing mycobacteria, including all the major human pathogens, but not three rapid-growing species. The amino sugar was a component of the arabinogalactan of the cell wall skeleton, and occurred at the level of about one residue per arabinogalactan chain. Its amino group was in the free, un-N-acetylated state. Examination of oligosaccharides released by partial acid hydrolysis of arabinogalactan by fast atom bombardment-MS and gas chromatography-MS identified a series of oligoarabinans, each possessing one GalN unit, linked to position 2 of arabinose. It is proposed that the GalN residues occur as stub branches of 1 → 5-linked arabinose chains in the arabinogalactan. Possible functions of GalN are discussed.
Research Article| October 15 1997
Galactosamine in walls of slow-growing mycobacteria
- Views Icon Views
- Share Icon Share
Philip DRAPER, Kay-Hooi KHOO, Delphi CHATTERJEE, Anne DELL, R. Howard MORRIS; Galactosamine in walls of slow-growing mycobacteria. Biochem J 15 October 1997; 327 (2): 519–525. doi: https://doi.org/10.1042/bj3270519
Download citation file: