Comparative analysis of metabolic pathways in different genomes yields important information on their evolution, on pharmacological targets and on biotechnological applications. In this study on glycolysis, three alternative ways of comparing biochemical pathways are combined: (1) analysis and comparison of biochemical data, (2) pathway analysis based on the concept of elementary modes, and (3) a comparative genome analysis of 17 completely sequenced genomes. The analysis reveals a surprising plasticity of the glycolytic pathway. Isoenzymes in different species are identified and compared; deviations from the textbook standard are detailed. Several potential pharmacological targets and by-passes (such as the Entner-Doudoroff pathway) to glycolysis are examined and compared in the different species. Archaean, bacterial and parasite specific adaptations are identified and described.
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October 1999
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Research Article|
September 24 1999
Pathway alignment: application to the comparative analysis of glycolytic enzymes
Thomas DANDEKAR
;
Thomas DANDEKAR
1
*EMBL, P.O. Box 102209, D-69012 Heidelberg, Germany
†Max Delbrück Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin-Buch, Germany
1To whom correspondence should be addressed at the EMBL address (e-mail dandekar@embl-heidelberg.de).
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Stefan SCHUSTER
;
Stefan SCHUSTER
†Max Delbrück Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin-Buch, Germany
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Berend SNEL
;
Berend SNEL
*EMBL, P.O. Box 102209, D-69012 Heidelberg, Germany
†Max Delbrück Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin-Buch, Germany
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Martijn HUYNEN
;
Martijn HUYNEN
*EMBL, P.O. Box 102209, D-69012 Heidelberg, Germany
†Max Delbrück Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin-Buch, Germany
‡Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
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Peer BORK
Peer BORK
*EMBL, P.O. Box 102209, D-69012 Heidelberg, Germany
†Max Delbrück Centre for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin-Buch, Germany
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Biochem J (1999) 343 (1): 115–124.
Article history
Received:
March 22 1999
Revision Received:
June 01 1999
Accepted:
July 15 1999
Citation
Thomas DANDEKAR, Stefan SCHUSTER, Berend SNEL, Martijn HUYNEN, Peer BORK; Pathway alignment: application to the comparative analysis of glycolytic enzymes. Biochem J 1 October 1999; 343 (1): 115–124. doi: https://doi.org/10.1042/bj3430115
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