ADP-ribosylation factor (ARF) 6 regulates plasma membrane trafficking and cortical actin formation by cycling between inactive GDP and active GTP-bound conformations. Here we show that agonist stimulation of phosphatidylinositide 3-kinase (PI 3-kinase) activates a pathway that leads to ARF6 activation. We also describe experiments that propose a central role in this pathway for the PI 3-kinase-dependent plasma membrane recruitment of the cytohesin-1 family of PtdIns(3,4,5)P3-binding ARF-exchange factors.
Research Article| January 25 2000
Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase
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Kanamarlapudi VENKATESWARLU, Peter J. CULLEN; Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochem J 1 February 2000; 345 (3): 719–724. doi: https://doi.org/10.1042/bj3450719
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