Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-transfected with EGFP-huntingtin-(CAG)72 and α-synuclein, a major component of Parkinson's disease aggregates. However, α-synuclein does not form aggregates by itself, nor does it appear in huntingtin inclusions in vitro.
α-Synuclein overexpression promotes aggregation of mutant huntingtin
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Robert A. FURLONG, Yolanda NARAIN, Julia RANKIN, Andreas WYTTENBACH, David C. RUBINSZTEIN; α-Synuclein overexpression promotes aggregation of mutant huntingtin. Biochem J 15 March 2000; 346 (3): 577–581. doi: https://doi.org/10.1042/bj3460577
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