The N-linked glycans on transferrin and α1-antitrypsin from patients with congenital disorders of glycosylation type I have increased fucosylation and branching relative to normal controls. The elevated levels of monofucosylated biantennary glycans are probably due to increased α-(1 → 6) fucosylation. The presence of bi- and trifucosylated triantennary and tetra-antennary glycans indicated that peripheral α-(1 → 3), as well as core α-(1 → 6), fucosylation is increased. Altered processing was observed on both the fully and underglycosylated glycoforms.
Congenital disorders of glycosylation type I leads to altered processing of N-linked glycans, as well as underglycosylation
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Philippa MILLS, Kevin MILLS, Peter CLAYTON, Andrew JOHNSON, David WHITEHOUSE, Bryan WINCHESTER; Congenital disorders of glycosylation type I leads to altered processing of N-linked glycans, as well as underglycosylation. Biochem J 15 October 2001; 359 (2): 249–254. doi: https://doi.org/10.1042/bj3590249
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