Dysregulation of the human transforming acidic coiled-coil (TACC) proteins is thought to be important in the evolution of breast cancer and multiple myeloma. However, the exact role of these proteins in the oncogenic process is currently unknown. Using the full-length TACC1 protein as bait to screen a human mammary epithelial cDNA library, we have identified two genes that are also amplified and overexpressed in tumours derived from different cellular origins. TACC1 interacts with the C-terminus of both the microtubule-associated colonic and hepatic tumour overexpressed (ch-TOG) protein, and the oncogenic transcription factor glioma amplified sequence 41/NuMA binding protein 1 (GAS41/NuBI1; where NuMA stands for nuclear mitotic apparatus protein 1). This suggests that the TACC proteins can form multiple complexes, dysregulation of which may be an important step during tumorigenesis.
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March 22 2002
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
Brenda LAUFFART
;
Brenda LAUFFART
1
∗Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, U.S.A.
1To whom correspondence should be addressed (e-mail Brenda.Lauffart@roswellpark.org).
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Scott J. HOWELL
;
Scott J. HOWELL
†Center for Molecular Genetics, ND40, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, U.S.A.
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Jason E. TASCH
;
Jason E. TASCH
†Center for Molecular Genetics, ND40, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, U.S.A.
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John K. COWELL
;
John K. COWELL
∗Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, U.S.A.
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Ivan H. STILL
Ivan H. STILL
∗Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, U.S.A.
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Biochem J (2002) 363 (1): 195–200.
Article history
Received:
December 11 2001
Accepted:
January 24 2002
Citation
Brenda LAUFFART, Scott J. HOWELL, Jason E. TASCH, John K. COWELL, Ivan H. STILL; Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. Biochem J 1 April 2002; 363 (1): 195–200. doi: https://doi.org/10.1042/bj3630195
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