High-mobility group A (HMGA) proteins are non-histone nuclear proteins that bind DNA and several transcription factors. They are involved in the regulation of chromatin structure and function. HMGA protein expression is low in normal adult tissues, but abundant during embryonic development and in several human tumours. Rearrangements of the HMGA genes have been frequently detected in human benign tumours of mesenchymal origin, e.g. lipomas, lung hamartomas and uterine leiomiomas. HMGA proteins have been implicated in the control of cell growth and differentiation of the pre-adipocytic cell line 3T3-L1. In an attempt to better understand the role of HMGA1 proteins in haematological neoplasias and in the differentiation of haematopietic cells, we have investigated their expression in human leukaemias and in leukaemic cell lines induced to terminal differentiation. Here we report HMGA1 overexpression in most fresh human leukaemias of different origin and in several leukaemic cell lines. Moreover, differentiation of three cell lines towards the megakaryocytic phenotype was associated with HMGA1 protein induction, whereas induction of erythroid and monocytic differentiation generally resulted in reduced HMGA1 expression.
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Research Article|
May 15 2003
High-mobility group A1 proteins are overexpressed in human leukaemias
Giovanna Maria PIERANTONI;
∗Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini, 5, 80131 Naples, Italy
2To whom correspondence should be addressed (e-mail gmpieran@unina.it).
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Valter AGOSTI;
Valter AGOSTI
1
†Dipartimento di Biochimica e Biotecnologie Mediche, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini 5, 80131 Naples, Italy
2To whom correspondence should be addressed (e-mail gmpieran@unina.it).
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Monica FEDELE;
Monica FEDELE
∗Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini, 5, 80131 Naples, Italy
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Heather BOND;
Heather BOND
‡Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catanzaro, via Tommaso Campanella, 88100 Catanzaro, Italy
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Irene CALIENDO;
Irene CALIENDO
§A.O. San Giuseppe Moscati, viale Italia, 83100 Avellino, Italy
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Gennaro CHIAPPETTA;
Gennaro CHIAPPETTA
¶Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, via M. Semmola, 80131 Naples, Italy
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Francesco LO COCO;
Francesco LO COCO
‖Dipartimento di Biotecnologie Cellulari ed Ematologia, Università “La Sapienza”, Rome, Italy
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Fabrizio PANE;
Fabrizio PANE
†Dipartimento di Biochimica e Biotecnologie Mediche, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini 5, 80131 Naples, Italy
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Maria Caterina TURCO;
Maria Caterina TURCO
†Dipartimento di Biochimica e Biotecnologie Mediche, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini 5, 80131 Naples, Italy
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Giovanni MORRONE;
Giovanni MORRONE
‡Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catanzaro, via Tommaso Campanella, 88100 Catanzaro, Italy
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Salvatore VENUTA;
Salvatore VENUTA
‡Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catanzaro, via Tommaso Campanella, 88100 Catanzaro, Italy
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Alfredo FUSCO
Alfredo FUSCO
∗Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, via S. Pansini, 5, 80131 Naples, Italy
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Biochem J (2003) 372 (1): 145–150.
Article history
Received:
September 25 2002
Revision Received:
January 08 2003
Accepted:
February 07 2003
Accepted Manuscript online:
February 07 2003
Citation
Giovanna Maria PIERANTONI, Valter AGOSTI, Monica FEDELE, Heather BOND, Irene CALIENDO, Gennaro CHIAPPETTA, Francesco LO COCO, Fabrizio PANE, Maria Caterina TURCO, Giovanni MORRONE, Salvatore VENUTA, Alfredo FUSCO; High-mobility group A1 proteins are overexpressed in human leukaemias. Biochem J 15 May 2003; 372 (1): 145–150. doi: https://doi.org/10.1042/bj20021493
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