Intracellular reactive oxygen species are generated as a by-product of normal metabolic processes and can both damage cellular constituents and function as important signalling species. This signalling often involves changes in the thiol redox balance. As an antioxidant, glutathione serves in maintaining the reduced state of cellular protein thiol groups. The paper by Cross and Templeton appearing in this issue of the Biochemical Journal describes a mechanism by which glutathionylation plays a key role in the regulation of the kinase activity of MEKK1 [MAP (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase kinase; MAP3K] in response to oxidative stresses. This type of post-translational-modification glutathionylation may represent a general mechanism by which protein kinase function can be regulated.
Skip Nav Destination
Article navigation
August 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Commentary|
July 27 2004
Protein kinase function and glutathionylation
Anthony N. ANSELMO;
Anthony N. ANSELMO
1Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, U.S.A.
Search for other works by this author on:
Melanie H. COBB
Melanie H. COBB
1
1Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, U.S.A.
1To whom correspondence should be sent (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
May 25 2004
Revision Received:
May 26 2004
Accepted:
May 26 2004
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2004
Biochem J (2004) 381 (3): e1.
Article history
Received:
May 25 2004
Revision Received:
May 26 2004
Accepted:
May 26 2004
Connected Content
This is a commentary on:
Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain
Citation
Anthony N. ANSELMO, Melanie H. COBB; Protein kinase function and glutathionylation. Biochem J 1 August 2004; 381 (3): e1. doi: https://doi.org/10.1042/BJ20040873
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.