Our quest to understand the complex inner workings of the cell depends on the development of new technologies that allow the study of global regulatory events as they happen within their native cellular environment. Post-translational processing of proteins by proteases is one such regulatory process that can control many aspects of basic cell biology. In this issue of the Biochemical Journal, Timmer et al. describe a new proteomic approach that can be used to globally monitor constitutive proteolytic events in vivo. Using bacterial, human, yeast and mouse cells, the authors show that this methodology provides a comprehensive map of constitutive trimming events mediated by regulatory proteases such as methionine aminopeptidase. This study also identifies previously uncharacterized processing events that highlight potential novel regulatory mechanisms mediated by proteolysis.
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Commentary|
September 12 2007
Finding the needles in the haystack: mapping constitutive proteolytic events in vivo
Matthew Bogyo
Matthew Bogyo
1
1Department of Pathology and Department of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, U.S.A.
1email mbogyo@stanford.edu
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Biochem J (2007) 407 (1): e1.
Article history
Received:
August 13 2007
Accepted:
August 14 2007
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This is a commentary on:
Profiling constitutive proteolytic events in vivo
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Matthew Bogyo; Finding the needles in the haystack: mapping constitutive proteolytic events in vivo. Biochem J 1 October 2007; 407 (1): e1. doi: https://doi.org/10.1042/BJ20071096
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