Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis.
Skip Nav Destination
Follow us on Twitter @Biochem_Journal
Article navigation
March 2008
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
Review Article|
February 12 2008
Genetic aspects of inflammation and cancer
Georgina L. Hold;
Georgina L. Hold
1Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, U.K.
Search for other works by this author on:
M. Emad El-Omar
M. Emad El-Omar
1
1Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, U.K.
1To whom correspondence should be addressed (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 01 2007
Revision Received:
November 23 2007
Accepted:
November 30 2007
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem J (2008) 410 (2): 225–235.
Article history
Received:
October 01 2007
Revision Received:
November 23 2007
Accepted:
November 30 2007
Citation
Georgina L. Hold, M. Emad El-Omar; Genetic aspects of inflammation and cancer. Biochem J 1 March 2008; 410 (2): 225–235. doi: https://doi.org/10.1042/BJ20071341
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Follow us on Twitter @Biochem_Journal
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() View past webinars > |