Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis.
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Review Article| February 12 2008
Genetic aspects of inflammation and cancer
Georgina L. Hold;
M. Emad El-Omar
M. Emad El-Omar 1
1Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, U.K.
1To whom correspondence should be addressed (email email@example.com).
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Publisher: Portland Press Ltd
Received: October 01 2007
Revision Received: November 23 2007
Accepted: November 30 2007
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2008 Biochemical Society
Georgina L. Hold, M. Emad El-Omar; Genetic aspects of inflammation and cancer. Biochem J 1 March 2008; 410 (2): 225–235. doi: https://doi.org/10.1042/BJ20071341
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