During low-to-high work transition in adult mammalian heart in vivo the concentrations of free ADP, ATP, PCr (phosphocreatine), Pi and NADH are essentially constant, in striking contrast with skeletal muscle. The direct activation by calcium ions of ATP usage and feedback activation of ATP production by ADP (and Pi) alone cannot explain this perfect homoeostasis. A comparison of the response to adrenaline (increase in rate-pressure product and [PCr]) of the intact beating perfused rat heart with the elasticities of the PCr producer and consumer to PCr concentration demonstrated that both the ATP/PCr-producing block and ATP/PCr-consuming block are directly activated to a similar extent during physiological heart activation. Our finding constitutes a direct evidence for the parallel-activation mechanism of the regulation of oxidative phosphorylation in heart postulated previously in a theoretical way.
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Research Article|
June 26 2008
Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply Available to Purchase
Bernard Korzeniewski;
Bernard Korzeniewski
*Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, France
†Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
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Véronique Deschodt-Arsac;
Véronique Deschodt-Arsac
*Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, France
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Guillaume Calmettes;
Guillaume Calmettes
*Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, France
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Jean-Michel Franconi;
Jean-Michel Franconi
*Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, France
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Philippe Diolez
Philippe Diolez
1
*Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, France
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
January 21 2008
Revision Received:
March 26 2008
Accepted:
March 31 2008
Accepted Manuscript online:
March 31 2008
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem J (2008) 413 (2): 343–347.
Article history
Received:
January 21 2008
Revision Received:
March 26 2008
Accepted:
March 31 2008
Accepted Manuscript online:
March 31 2008
Citation
Bernard Korzeniewski, Véronique Deschodt-Arsac, Guillaume Calmettes, Jean-Michel Franconi, Philippe Diolez; Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. Biochem J 15 July 2008; 413 (2): 343–347. doi: https://doi.org/10.1042/BJ20080162
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