The family of mammalian bicarbonate transport proteins are involved in a wide-range of physiological processes. The importance of bicarbonate transport follows from the biochemistry of HCO3− itself. Bicarbonate is the waste product of mitochondrial respiration. HCO3− undergoes pH-dependent conversion into CO2 and in doing so converts from a membrane impermeant anion into a gas that can diffuse across membranes. The CO2–HCO3− equilibrium forms the most important pH buffering system of our bodies. Bicarbonate transport proteins facilitate the movement of membrane-impermeant HCO3− across membranes to accelerate disposal of waste CO2, control cellular and whole-body pH, and to regulate fluid movement and acid/base secretion. Defects of bicarbonate transport proteins manifest in diseases of most organ systems. Fourteen gene products facilitate mammalian bicarbonate transport, whose physiology and pathophysiology is discussed in the present review.
Review Article| December 23 2008
Bicarbonate transport in cell physiology and disease
Joseph R. Casey
Joseph R. Casey 1
*Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton, Canada T6G 2H7
†Department of Biochemistry, University of Alberta, Edmonton, Canada T6G 2H7
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Emmanuelle Cordat, Joseph R. Casey; Bicarbonate transport in cell physiology and disease. Biochem J 15 January 2009; 417 (2): 423–439. doi: https://doi.org/10.1042/BJ20081634
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