Membrane fusion underlies many cellular events, including secretion, exocytosis, endocytosis, organelle reconstitution, transport from endoplasmic reticulum to Golgi and nuclear envelope formation. A large number of investigations into membrane fusion indicate various roles for individual members of the phosphoinositide class of membrane lipids. We first review the phosphoinositides as membrane recognition sites and their regulatory functions in membrane fusion. We then consider how modulation of phosphoinositides and their products may affect the structure and dynamics of natural membranes facilitating fusion. These diverse roles underscore the importance of these phospholipids in the fusion of biological membranes.
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Review Article| February 11 2009
Phosphatidylinositol metabolism and membrane fusion
Banafshé Larijani 1
†Cell Biophysics Laboratory, Lincoln's Inn Fields Laboratories, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, U.K.
1Correspondence may be addressed to either of these authors (email firstname.lastname@example.org or email@example.com).
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Dominic Poccia, Banafshé Larijani; Phosphatidylinositol metabolism and membrane fusion. Biochem J 1 March 2009; 418 (2): 233–246. doi: https://doi.org/10.1042/BJ20082105
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