Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors and on dietary selenium. Although the functions of many selenoproteins are unknown, several disorders involving changes in selenoprotein structure, activity or expression have been reported. Selenium deficiency and mutations or polymorphisms in selenoprotein genes and synthesis cofactors are implicated in a variety of diseases, including muscle and cardiovascular disorders, immune dysfunction, cancer, neurological disorders and endocrine function. Members of this unusual family of proteins have roles in a variety of cell processes and diseases.
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Review Article|
July 29 2009
Regulation and function of selenoproteins in human disease
Frederick P. Bellinger
;
Frederick P. Bellinger
1
1
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, U.S.A.1
To whom correspondence should be addressed (email fb@hawaii.edu).
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Arjun V. Raman
;
Arjun V. Raman
1
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, U.S.A.
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Mariclair A. Reeves
;
Mariclair A. Reeves
1
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, U.S.A.
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Marla J. Berry
Marla J. Berry
1
Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, U.S.A.
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Biochem J (2009) 422 (1): 11-22.
Article history
Received:
February 06 2009
Revision Received:
June 12 2009
Accepted:
June 15 2009
Citation
Frederick P. Bellinger, Arjun V. Raman, Mariclair A. Reeves, Marla J. Berry; Regulation and function of selenoproteins in human disease. Biochem J 15 August 2009; 422 (1): 11–22. doi: https://doi.org/10.1042/BJ20090219
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