Gram-negative bacteria have evolved diverse secretion systems/machineries to translocate substrates across the cell envelope. These various machineries fulfil a wide variety of functions but are also essential for pathogenic bacteria to infect human or plant cells. Secretion systems, of which there are seven, utilize one of two secretion mechanisms: (i) the one-step mechanism, whereby substrates are translocated directly from the bacterial cytoplasm to the extracellular medium or into the eukaryotic target cell; (ii) the two-step mechanism, whereby substrates are first translocated across the bacterial inner membrane; once in the periplasm, substrates are targeted to one of the secretion systems that mediate transport across the outer membrane and released outside the bacterial cell. The present review provides an example for each of these two classes of secretion systems and contrasts the various solutions evolved to secrete substrates.
Skip Nav Destination
Article navigation
February 2010
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review Article|
January 15 2010
Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis
Ana Toste Rêgo;
Ana Toste Rêgo
1
1Institute of Structural and Molecular Biology, Birkbeck and University College London, Malet Street, London, WC1E 7HX, U.K.
Search for other works by this author on:
Vidya Chandran;
Vidya Chandran
1
1Institute of Structural and Molecular Biology, Birkbeck and University College London, Malet Street, London, WC1E 7HX, U.K.
Search for other works by this author on:
Gabriel Waksman
1Institute of Structural and Molecular Biology, Birkbeck and University College London, Malet Street, London, WC1E 7HX, U.K.
2To whom correspondence should be addressed (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 06 2009
Revision Received:
November 16 2009
Accepted:
November 18 2009
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem J (2010) 425 (3): 475–488.
Article history
Received:
October 06 2009
Revision Received:
November 16 2009
Accepted:
November 18 2009
Citation
Ana Toste Rêgo, Vidya Chandran, Gabriel Waksman; Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. Biochem J 1 February 2010; 425 (3): 475–488. doi: https://doi.org/10.1042/BJ20091518
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.