At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network has been implicated in all of these areas. While each of the Wnt-dependent signalling pathways are being individually delineated in a range of experimental systems, our understanding of how they integrate and regulate cellular metabolism is still in its infancy. In the present review we reassess the roles of Wnt signalling in functionally linking cellular metabolism to tissue development and function.
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Review Article| March 15 2010
Wnt signalling and the control of cellular metabolism
Jaswinder K. Sethi ;
Jaswinder K. Sethi 1
1Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Level 4, Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K.
1To whom correpondence should be addressed (email firstname.lastname@example.org).
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Jaswinder K. Sethi, Antonio Vidal-Puig; Wnt signalling and the control of cellular metabolism. Biochem J 1 April 2010; 427 (1): 1–17. doi: https://doi.org/10.1042/BJ20091866
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