In humans, there are 48 members of the superfamily of nuclear receptors. These ligand-activated transcription factors help to integrate our growth, reproduction and metabolism via environmental, nutritional and intrinsic cues. It is therefore not surprising that nuclear receptors are commonly used as drug targets. However, perhaps in the rush to discover new drugs that target these receptors, we sometimes lose sight of their ‘real’ physiological ligands. In this issue of the Biochemical Journal Goto et al. present evidence that the isoprenoid FPP (farnesyl pyrophosphate) may be a bona fide ligand for the master controller of adipocyte differentiation PPARγ (peroxisome-proliferator-activated receptor γ). This work has wide-ranging implications not only for obesity and diabetes, but also for osteoporosis and the control of circadian rhythms in which PPARγ also plays an important role.
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August 2011
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July 27 2011
Isoprenoid is a perfect fit for fat factor Available to Purchase
Andrew J. Brown
Andrew J. Brown
1
1School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
1email [email protected]
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Publisher: Portland Press Ltd
Received:
June 06 2011
Accepted:
June 17 2011
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem J (2011) 438 (1): e1–e3.
Article history
Received:
June 06 2011
Accepted:
June 17 2011
Connected Content
This is a correction to:
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist
Citation
Andrew J. Brown; Isoprenoid is a perfect fit for fat factor. Biochem J 15 August 2011; 438 (1): e1–e3. doi: https://doi.org/10.1042/BJ20110996
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