The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family includes four vertebrate isoforms (RSK1, RSK2, RSK3 and RSK4), and single family member orthologues are also present in Drosophila and Caenorhabditis elegans. The RSK isoforms are downstream effectors of the Ras/ERK (extracellular-signal-regulated kinase) signalling pathway. Significant advances in the field of RSK signalling have occurred in the past few years, including several new functions ascribed to the RSK isoforms, the discovery of novel protein substrates and the implication of different RSK isoforms in cancer. Collectively, these new findings increase the diversity of biological functions regulated by RSK, and highlight potential new directions of research. In the present paper, we review the structure, expression and activation mechanisms of the RSK isoforms, and discuss their physiological roles on the basis of established substrates and recent discoveries.
Review Article| December 21 2011
Regulation and function of the RSK family of protein kinases
Philippe P. Roux
Philippe P. Roux 1
†Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
‡Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
1To whom correspondence should be addressed (email firstname.lastname@example.org).
Search for other works by this author on:
- Views Icon Views
- Share Icon Share
Yves Romeo, Xiaocui Zhang, Philippe P. Roux; Regulation and function of the RSK family of protein kinases. Biochem J 15 January 2012; 441 (2): 553–569. doi: https://doi.org/10.1042/BJ20110289
Download citation file: