Flaviviruses are a genus of (+)ssRNA (positive ssRNA) enveloped viruses that replicate in the cytoplasm of cells of diverse species from arthropods to mammals. Many are important human pathogens such as DENV-1–4 (dengue virus types 1–4), WNV (West Nile virus), YFV (yellow fever virus), JEV (Japanese encephalitis virus) and TBEV (tick-borne encephalitis). Given their RNA genomes it is not surprising that flaviviral life cycles revolve around critical RNA transactions. It is these we highlight in the present article. First, we summarize the mechanisms governing flaviviral replication and the central role of conserved RNA elements and viral protein–RNA interactions in RNA synthesis, translation and packaging. Secondly, we focus on how host RNA-binding proteins both benefit and inhibit flaviviral replication at different stages of their life cycle in mammalian hosts. Thirdly, we cover recent studies on viral non-coding RNAs produced in flavivirus-infected cells and how these RNAs affect various aspects of cellular RNA metabolism. Together, the article puts into perspective the central role of flaviviral RNAs in modulating both viral and cellular functions.
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September 2014
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August 07 2014
Flaviviral RNAs: weapons and targets in the war between virus and host
Katell Bidet;
Katell Bidet
1
*Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857
†NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456
1Correspondence may be addressed to either of these authors (email [email protected] or [email protected]/[email protected]).
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Mariano A. Garcia-Blanco
Mariano A. Garcia-Blanco
1
*Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857
†NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456
‡Center for RNA Biology, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A.
§Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A.
∥Department of Medicine, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A.
1Correspondence may be addressed to either of these authors (email [email protected] or [email protected]/[email protected]).
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Publisher: Portland Press Ltd
Received:
April 07 2014
Revision Received:
June 06 2014
Accepted:
June 12 2014
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem J (2014) 462 (2): 215–230.
Article history
Received:
April 07 2014
Revision Received:
June 06 2014
Accepted:
June 12 2014
Citation
Katell Bidet, Mariano A. Garcia-Blanco; Flaviviral RNAs: weapons and targets in the war between virus and host. Biochem J 1 September 2014; 462 (2): 215–230. doi: https://doi.org/10.1042/BJ20140456
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