The present study establishes that the avβ6 integrin associates with the transforming growth factor (TGF)β receptor (TβR) and is required for the activation of the TGFβ–Smad3 signalling pathway. This causes up-regulation of matrix metalloproteinase (MMP)2 and as a result avβ6 promotes cell migration in an MMP2-dependent manner.

Keywords:
integrins, matrix metalloproteinase 2 (MMP2), prostate cancer (PrCa), SMAD3, transforming growth factor (TGF) β1 receptor
© The Authors Journal compilation © 2015 Biochemical Society
2015
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