The present study establishes that the avβ6 integrin associates with the transforming growth factor (TGF)β receptor (TβR) and is required for the activation of the TGFβ–Smad3 signalling pathway. This causes up-regulation of matrix metalloproteinase (MMP)2 and as a result avβ6 promotes cell migration in an MMP2-dependent manner.
αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression
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Anindita Dutta, Jing Li, Carmine Fedele, Aejaz Sayeed, Amrita Singh, Shelia M. Violette, Thomas D. Manes, Lucia R. Languino; αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression. Biochem J 15 March 2015; 466 (3): 525–536. doi: https://doi.org/10.1042/BJ20140698
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