In this study we demonstrate that ischemia-induced impairment of intercellular communication between cardiomyocytes is due to the degradation of the gap junction protein Connexin43 by autophagy, which according to the severity of the insult involves different molecular partners.
Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Tania Martins-Marques, Steve Catarino, Monica Zuzarte, Carla Marques, Paulo Matafome, Paulo Pereira, Henrique Girão; Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes. Biochem J 15 April 2015; 467 (2): 231–245. doi: https://doi.org/10.1042/BJ20141370
Download citation file: