Transport of the anti-cancer agent 3-bromopyruvate (3BP) in breast cancer cells is mediated by monocarboxylate transporter (MCT)-1 activated by glycosylated chaperone cluster of differentiation (CD) 147. The extracellular acidic pH increases the affinity for 3BP uptake enhancing its selective cytotoxic effect in tumour cells.
The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
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João Azevedo-Silva, Odília Queirós, Ana Ribeiro, Fátima Baltazar, Ko H. Young, Peter L. Pedersen, Ana Preto, Margarida Casal; The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH. Biochem J 15 April 2015; 467 (2): 247–258. doi: https://doi.org/10.1042/BJ20140921
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