PAK4 [p21 protein (Cdc42/Rac)-activated kinase 4] and partitioning defective (Par) 6B are required for apical junction assembly in epithelial cells. PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (cell division cycle 42). This could provide dynamic turnover of Par6B at junctions and/or promote Par6B interactions with alternative binding partners.

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