Using mouse embryonic fibroblasts (MEFs) from DJ1-knockout mice, in the present study, we show that DJ1, by binding with Foxo3a (forkhead box O3a), transcriptionally activates pink1 (phosphatase and tensin homologue deleted on chromosome 10-induced protein kinase-1) gene. Moreover, we demonstrate that, by promoting pink1 expression, DJ1 represses the rate of glycolysis and cell proliferation.
DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1
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Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Daniel Jimenez-Blasco, Emilio Fernandez, Angeles Almeida, Juan P. Bolaños; DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1. Biochem J 15 April 2015; 467 (2): 303–310. doi: https://doi.org/10.1042/BJ20141025
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