We demonstrate that retrocyclins (RCs), promising therapeutic peptides, neutralize bacterial toxins by inducing their unfolding and exposing hydrophobic regions, normally buried in the molecule interior, to solvents. RC-induced toxin unfolding leads to toxin precipitation, proneness to proteolytic degradation and abrogated activity.
Skip Nav Destination
Research Article| April 02 2015
Retrocyclins neutralize bacterial toxins by potentiating their unfolding
Dmitri S. Kudryashov
Dmitri S. Kudryashov 1
*Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, U.S.A.
∥Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, U.S.A.
¶Public Health Preparedness for Infectious Diseases Program, The Ohio State University, Columbus, OH 43210, U.S.A.
1To whom correspondence should be addressed (email email@example.com).
Search for other works by this author on:
- Views Icon Views
- Share Icon Share
Elena Kudryashova, Stephanie Seveau, Wuyuan Lu, Dmitri S. Kudryashov; Retrocyclins neutralize bacterial toxins by potentiating their unfolding. Biochem J 15 April 2015; 467 (2): 311–320. doi: https://doi.org/10.1042/BJ20150049
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article