tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL), like Mtch2, promotes the activating conformational change of tBid.
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
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Aisha Shamas-Din, Scott Bindner, Xiaoke Chi, Brian Leber, David W. Andrews, Cécile Fradin; Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax. Biochem J 1 May 2015; 467 (3): 495–505. doi: https://doi.org/10.1042/BJ20141291
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