Deregulated inflammatory response plays a pivotal role in the initiation, development and progression of tumours. Potential molecular mechanism(s) that drive the establishment of an inflammatory-tumour microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer, and their activation and/or deactivation are influenced by both extrinsic (i.e. environmental and lifestyle) and intrinsic (i.e. hereditary) factors. At present, the research pertaining to inflammation-associated cancers is accumulating at an exponential rate. Interest stems from hope that new therapeutic strategies against molecular mediators can be identified to assist in cancer treatment and patient management. The present review outlines the various molecular and cellular inflammatory mediators responsible for tumour initiation, progression and development, and discusses the critical role of chronic inflammation in tumorigenesis.
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May 2015
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Review Article|
May 05 2015
Analysis of the intricate relationship between chronic inflammation and cancer
Edna Zhi Pei Chai;
Edna Zhi Pei Chai
*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
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Kodappully Sivaraman Siveen;
Kodappully Sivaraman Siveen
*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
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Muthu K. Shanmugam;
Muthu K. Shanmugam
*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
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Frank Arfuso;
Frank Arfuso
†School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia
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Gautam Sethi
Gautam Sethi
1
*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
†School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 29 2014
Revision Received:
February 26 2015
Accepted:
March 05 2015
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem J (2015) 468 (1): 1–15.
Article history
Received:
October 29 2014
Revision Received:
February 26 2015
Accepted:
March 05 2015
Citation
Edna Zhi Pei Chai, Kodappully Sivaraman Siveen, Muthu K. Shanmugam, Frank Arfuso, Gautam Sethi; Analysis of the intricate relationship between chronic inflammation and cancer. Biochem J 15 May 2015; 468 (1): 1–15. doi: https://doi.org/10.1042/BJ20141337
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