Excessive osteoclast formation and bone resorption are key causes of osteoporosis. Natural compounds can serve as alternative therapeutic agents for the prevention and treatment of osteoporosis, and some natural compounds may have advantages over traditional drugs. In the present paper, we report that the natural compound GBA (gambogic acid), which is bioavailable, effective and less toxic, inhibits osteoclast formation, thereby attenuating osteoclastic bone resorption in vitro. Further in vivo studies demonstrated that GBA prevented ovariectomy-induced bone loss in a dose-dependent manner. Moreover, we demonstrated that GBA suppressed RANKL (receptor activator of nuclear factor κB ligand)-induced JNK (c-Jun N-terminal kinase), p38 and Akt phosphorylation. Taken together, our results demonstrate that GBA inhibits osteoclast formation in vitro and in vivo, suggesting that it is of potential value in the treatment of osteoclast-related diseases.
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Research Article|
July 23 2015
Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways
Jianjun Ma;
Jianjun Ma
1
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, People's Republic of China
†Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, People's Republic of China
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Yan Ma;
Yan Ma
1
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, People's Republic of China
†Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, People's Republic of China
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Xuqiang Liu;
Xuqiang Liu
‡Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People's Republic of China
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Shuai Chen;
Shuai Chen
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, People's Republic of China
†Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, People's Republic of China
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Chao Liu;
Chao Liu
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, People's Republic of China
†Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, People's Republic of China
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An Qin;
An Qin
2
‡Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People's Republic of China
2Correspondence may be addressed to either of these authors (email [email protected] or [email protected]).
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Shunwu Fan
Shunwu Fan
2
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, People's Republic of China
†Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, People's Republic of China
2Correspondence may be addressed to either of these authors (email [email protected] or [email protected]).
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Publisher: Portland Press Ltd
Received:
February 05 2015
Revision Received:
May 27 2015
Accepted:
June 01 2015
Accepted Manuscript online:
June 10 2015
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2015 Authors; published by Portland Press Limited
2015
Biochem J (2015) 469 (3): 399–408.
Article history
Received:
February 05 2015
Revision Received:
May 27 2015
Accepted:
June 01 2015
Accepted Manuscript online:
June 10 2015
Citation
Jianjun Ma, Yan Ma, Xuqiang Liu, Shuai Chen, Chao Liu, An Qin, Shunwu Fan; Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways. Biochem J 1 August 2015; 469 (3): 399–408. doi: https://doi.org/10.1042/BJ20150151
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