The a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) family of metzincins are complex secreted proteins that have diverse functions during development. The hyalectanases (ADAMTS1, 4, 5, 8, 9, 15 and 20) are a subset of this family that have enzymatic activity against hyalectan proteoglycans, the processing of which has important implications during development. This review explores the evolution, expression and developmental functions of the ADAMTS family, focusing on the ADAMTS hyalectanases and their substrates in diverse species. This review gives an overview of how the family and their substrates evolved from non-vertebrates to mammals, the expression of the hyalectanases and substrates in different species and their functions during development, and how these functions are conserved across species.
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Review Article|
July 12 2016
The ADAMTS hyalectanase family: biological insights from diverse species
Carolyn M. Dancevic;
Carolyn M. Dancevic
1
*Centre for Molecular and Medical and School of Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3217, Australia
1To whom correspondence should be addressed (email carolyn.dancevic@deakin.edu.au).
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Daniel R. McCulloch;
Daniel R. McCulloch
*Centre for Molecular and Medical and School of Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3217, Australia
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Alister C. Ward
Alister C. Ward
*Centre for Molecular and Medical and School of Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3217, Australia
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Publisher: Portland Press Ltd
Received:
February 22 2016
Revision Received:
March 24 2016
Accepted:
March 29 2016
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Biochem J (2016) 473 (14): 2011–2022.
Article history
Received:
February 22 2016
Revision Received:
March 24 2016
Accepted:
March 29 2016
Citation
Carolyn M. Dancevic, Daniel R. McCulloch, Alister C. Ward; The ADAMTS hyalectanase family: biological insights from diverse species. Biochem J 15 July 2016; 473 (14): 2011–2022. doi: https://doi.org/10.1042/BCJ20160148
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