Aging is often accompanied by a decline in mitochondrial mass and function in different tissues. Additionally, cell resistance to stress is frequently found to be prevented by higher mitochondrial respiratory capacity. These correlations strongly suggest mitochondria are key players in aging and senescence, acting by regulating energy homeostasis, redox balance and signalling pathways central in these processes. However, mitochondria display a wide array of functions and signalling properties, and the roles of these different characteristics are still widely unexplored. Furthermore, differences in mitochondrial properties and responses between tissues and cell types, and how these affect whole body metabolism are also still poorly understood. This review uncovers aspects of mitochondrial biology that have an impact upon aging in model organisms and selected mammalian cells and tissues.
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October 2016
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A representation of a mitochondrion. In this issue, Kowaltowski et al. review aspects of mitochondrial biology that have an impact on aging in model organisms and selected mammalian cells and tissues. See pp. 3421–3449 for further details.
Review Article|
October 11 2016
Mitochondrial form, function and signalling in aging Available to Purchase
Ignacio Amigo;
Ignacio Amigo
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Fernanda M. da Cunha;
Fernanda M. da Cunha
*
2Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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Maria Fernanda Forni;
Maria Fernanda Forni
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Wilson Garcia-Neto;
Wilson Garcia-Neto
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Pâmela A. Kakimoto;
Pâmela A. Kakimoto
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Luis A. Luévano-Martínez;
Luis A. Luévano-Martínez
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Felipe Macedo;
Felipe Macedo
*
2Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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Sergio L. Menezes-Filho;
Sergio L. Menezes-Filho
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Julia Peloggia;
Julia Peloggia
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Alicia J. Kowaltowski
Alicia J. Kowaltowski
*
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
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Publisher: Portland Press Ltd
Received:
June 13 2016
Revision Received:
June 13 2016
Accepted:
June 17 2016
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2016
Biochem J (2016) 473 (20): 3421–3449.
Article history
Received:
June 13 2016
Revision Received:
June 13 2016
Accepted:
June 17 2016
Citation
Ignacio Amigo, Fernanda M. da Cunha, Maria Fernanda Forni, Wilson Garcia-Neto, Pâmela A. Kakimoto, Luis A. Luévano-Martínez, Felipe Macedo, Sergio L. Menezes-Filho, Julia Peloggia, Alicia J. Kowaltowski; Mitochondrial form, function and signalling in aging. Biochem J 15 October 2016; 473 (20): 3421–3449. doi: https://doi.org/10.1042/BCJ20160451
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