Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonstrated to be key factors for oncogenesis. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences
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Matthias Dedobbeleer, Estelle Willems, Stephen Freeman, Arnaud Lombard, Nicolas Goffart, Bernard Rogister; Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences. Biochem J 1 September 2017; 474 (17): 2903–2924. doi: https://doi.org/10.1042/BCJ20170112
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