The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.
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July 2020
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Cover Image
Cover Image
3D reconstruction of septin filaments, which orientation is colour coded, bound to liposomes (purple) and obtained by cryo-electron tomography. The polymerization of Shs1 capped protomers is enhanced in the presence of biomimetic membranes. For more information, see the article by Taveneau and colleagues in this issue (pp. 2697–2714). The image was provided by Aurélie Bertin.
Review Article|
July 29 2020
Gut microbiome a promising target for management of respiratory diseases
Riddhi Trivedi;
Riddhi Trivedi
Shobhaben Pratapbhai Patel-School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra, India
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Kalyani Barve
Shobhaben Pratapbhai Patel-School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra, India
Correspondence: Kalyani Barve ([email protected])
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Publisher: Portland Press Ltd
Received:
May 28 2020
Revision Received:
July 07 2020
Accepted:
July 08 2020
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2020
Biochem J (2020) 477 (14): 2679–2696.
Article history
Received:
May 28 2020
Revision Received:
July 07 2020
Accepted:
July 08 2020
Citation
Riddhi Trivedi, Kalyani Barve; Gut microbiome a promising target for management of respiratory diseases. Biochem J 31 July 2020; 477 (14): 2679–2696. doi: https://doi.org/10.1042/BCJ20200426
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