The detailed metabolic characterization of the glucagon receptor (Gcgr)V369M+/+ mutant mice described in Lin et al. in the Biochemical Journal is of interest and resulting in the expected metabolic profile. We would like to point out that these mice might also be extremely useful as a precision medicine model of mild Mahvash disease, a rare hereditary pancreatic neuroendocrine tumor syndrome characterized by inactivating mutations in the glucagon receptor. Further characterization of pancreas morphology and histology in the GcgrV369M+/+ mice at more advanced ages will be critically important to understand mild Mahvash disease in humans.
Correspondence| August 12 2020
The V369M Gcgr knock-in mice are a precision medicine model of mild Mahvash disease
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Run Yu; The V369M Gcgr knock-in mice are a precision medicine model of mild Mahvash disease. Biochem J 14 August 2020; 477 (15): 2873–2874. doi: https://doi.org/10.1042/BCJ20200522
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