Cell-penetrating peptides (CPPs) are short peptides able to cross the cellular membranes without any interaction with specific receptors. Thanks to their ability to transport various cargo inside the cells are emerged as powerful therapeutic agents alternative to small molecules. In recent years, numerous preclinical studies provided promising results for the treatment of various human diseases. Several CPP-conjugated compounds are under clinical trials.
Commentary| April 23 2020
Cell-penetrating peptides: two faces of the same coin
Giovanna Maria Pierantoni;
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Giovanna Maria Pierantoni, Simona Paladino; Cell-penetrating peptides: two faces of the same coin. Biochem J 30 April 2020; 477 (8): 1363–1366. doi: https://doi.org/10.1042/BCJ20200006
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