In recent years, significant strides in both conceptual understanding and technological capabilities have bolstered our comprehension of the factors underpinning cancer initiation and progression. While substantial insights have unraveled the molecular mechanisms driving carcinogenesis, there has been an overshadowing of the critical contribution made by epigenetic pathways, which works in concert with genetics. Mounting evidence demonstrates cancer as a complex interplay between genetics and epigenetics. Notably, epigenetic elements play a pivotal role in governing alternative pre-mRNA splicing, a primary contributor to protein diversity. In this review, we have provided detailed insights into the bidirectional communication between epigenetic modifiers and alternative splicing, providing examples of specific genes and isoforms affected. Notably, succinct discussion on targeting epigenetic regulators and the potential of the emerging field of epigenome editing to modulate splicing patterns is also presented. In summary, this review offers valuable insights into the intricate interplay between epigenetics and alternative splicing in cancer, paving the way for novel approaches to understanding and targeting this critical process.
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November 2024
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Cover Image
Cover Image
The cover image highlights the tetramer of soybean serine hydroxymethyltransferase and shows the changes in the active site due to a mutation of residue 285. Substitution of Pro285 with a serine results in multiple structural changes, including a dramatic rearrangement of the PLP cofactor. For further information, see the article by Samarakoon and colleagues (pp. 1557–1568) in this issue. The image is provided by Lesa Beamer.
Review Article|
October 18 2024
Epigenetics and alternative splicing in cancer: old enemies, new perspectives
Madhura R. Pandkar;
Madhura R. Pandkar
*
Conceptualization, Writing - original draft, Project administration, Writing - review & editing
Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh 462066, India
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Sanjeev Shukla
Conceptualization, Supervision, Funding acquisition, Writing - original draft, Project administration, Writing - review & editing
Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh 462066, India
Correspondence: Sanjeev Shukla ([email protected])
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Publisher: Portland Press Ltd
Received:
May 08 2024
Revision Received:
September 30 2024
Accepted:
October 07 2024
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2024
Biochem J (2024) 481 (21): 1497–1518.
Article history
Received:
May 08 2024
Revision Received:
September 30 2024
Accepted:
October 07 2024
Citation
Madhura R. Pandkar, Sanjeev Shukla; Epigenetics and alternative splicing in cancer: old enemies, new perspectives. Biochem J 6 November 2024; 481 (21): 1497–1518. doi: https://doi.org/10.1042/BCJ20240221
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