In vitro reconstruction of the l-lactate/pyruvate shuttle has been performed, which allows NADH oxidation outside rat heart mitochondria. Such a shuttle occurs due to the combined action of the novel mitochondrial l-lactate/pyruvate antiporter, which differs from the monocarboxylate carrier, and the mitochondrial l-lactate dehydrogenase. The rate of l-lactate/pyruvate antiport proved to regulate the shuttle in vitro.

Keywords:
lactate mitochondrial transport, lactate mitochondrial uptake, lactate/pyruvate antiporter, reducing-equivalent transfer system
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The Biochemical Society, London ©2002
2002
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