1. β-Amyrin synthesized by pea seedlings in the presence of (3RS)-[2−14C,(4R)-4−3H1]mevalonic acid (for nomenclature see Cahn, Ingold & Prelog, 1956) was subjected to a series of degradations to locate the positions within the molecule of the incorporated tritium. 2. The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.
Research Article| February 01 1968
The biosynthesis of β-amyrin. Mechanism of squalene cyclization
H H Rees;
Biochem J (1968) 106 (3): 659–665.
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H H Rees, G. Britton, T W Goodwin; The biosynthesis of β-amyrin. Mechanism of squalene cyclization. Biochem J 1 February 1968; 106 (3): 659–665. doi: https://doi.org/10.1042/bj1060659
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