GSH added to rat liver homogenates inhibited respiration and increased GSSG formation approximately proportionally to the amount of GSH added; the effect was increased by added magnesium chloride. Added NADPH and citrate decreased GSSG formation and increased respiration; 6·0mm-nicotinamide prevented GSSG formation and increased respiration. There was a negative correlation between GSSG formation and oxygen uptake. It is suggested that the decrease in oxygen uptake is mainly due to GSSG concentration and also that in vivo a GSH–GSSG steady state occurs.
Research Article| August 01 1969
A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates
Biochem J (1969) 114 (1): 5–9.
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R E Pinto, W Bartley; A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates. Biochem J 1 August 1969; 114 (1): 5–9. doi: https://doi.org/10.1042/bj1140005
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