1. Four new metabolites of phenacetin in the urine of the rat are described; these are (i) N-acetyl-S-ethylcysteine, (ii) quinol, (iii) acetamide and (iv) probably N-acetyl-S-2-(4-ethoxyacetanilido)cysteine S-oxide. 2. Metabolites (i), (iii) and (iv) were characterized and estimated by g.l.c., by t.l.c., by paper chromatography, by chemical reactions or by radioactive techniques after administration to rats of [ethyl-14C]phenacetin and [acetyl-3H]phenacetin; metabolite (ii), which was excreted mainly as conjugates of sulphuric acid and glucosiduronic acid, was measured by paper chromatography and characteristic colour reactions after enzymic and chemical hydrolysis of the conjugates. 3. Small amounts of azoxy-4-[ethyl-14C]ethoxybenzene and an unknown metabolite were also found in the urine of rats after administration of [ethyl-14C]phenacetin. 4. The likely mechanisms and some biological implications of these metabolic reactions are discussed.
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April 1971
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Research Article|
April 01 1971
Some new aspects of the metabolism of phenacetin in the rat
R. Nery
R. Nery
1Chester Beatty Research Institute, Institute of Cancer Research, Fulham Road, London S.W.3, U.K.
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Publisher: Portland Press Ltd
© 1971 London: The Biochemical Society
1971
Biochem J (1971) 122 (3): 317–326.
Citation
R. Nery; Some new aspects of the metabolism of phenacetin in the rat. Biochem J 1 April 1971; 122 (3): 317–326. doi: https://doi.org/10.1042/bj1220317
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